That depends what program and tools you’re using! In my case I tend to just hand pick every colour, find it’s easier than trying to blend. If I do need to mix stuff, the SAI brushes I use have a tiny bit of the colour blend setting on them (but it’s really just enough to soften the edge or give a hard blend). It makes the edge between the colours have a little blob of whatever is in between, so in the event I do need a mixed colour I’ll use the colour picker tool to grab it from there…if that makes sense ^^’ don’t really work with mixing a lot, most of what I do is fairly solid stuff.

I’ve got a few videos up that show when I’m doing the line work, like this. Usually use the first brush I mention here. I sometimes work with different bits separately then merge the layers down. One of the last steps I generally do is colour the lines with either a clipping mask or opacity lock, up until then I leave the lines black. And uh…that’s about it really :\ can’t think of anything else…

It’s not a stupid question! bit hard for me to say though since I’ve been fiddling with my SAI brushes a lot lately ^^’ here are the most common brushes I use:

The first one is for lines and flat shading, and I use all of them for general shading/painting. The last one I only use for lines on my comic pages (and only at 600dpi). I’ve got some of my other brushes here. If there’s a specific picture anyone is interested I can try and be more specific! :) I do tend to mess around with these settings while I work though.